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mare kosmetikVan Rooj et. al. demonstrated that the inhibition of miR-208a by systemic delivery of locked nucleic acid–modified antisense oligonucleotide prevented cardiac remodeling in a rat model of LV failure. This technology also prevented pathological myosin switching and cardiac remodeling, while improving cardiac function .
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LBBAP including left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP) has been proved to be effective for CRT. LBBP is preferred due to its physiological pacing modality, while LVSP can be reasonable in those LBB cannot be capture. Combining LVSP and LV pacing (LVP) via additional coronary sinus (CS) lead may provide more benefits.
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