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CpG motif DNA or lipopolysaccharide (LPS) from bacteria stimulate DCs to upregulate a number of critical immunomodulatory molecules, including, for example, increased expression of CD80 and CD86 and increased secretion of IL-12 and TNF- α. 1, 2 DCs interact with specific T cell subsets to initiate or augment antigen-specific immune .
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Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and play crucial roles in both the promotion of immune defense and the maintenance of immune tolerance.
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